Enclomiphene vs. Clomiphene: Which One Is Right for You?

We are here to support patients and providers in evaluating enclomiphene and clomiphene for treatment of low testosterone, fertility complications, or hormonal imbalance, which both enclomiphene and clomiphene can treat effectively in slightly different ways. At Allure Compounding Pharmacy, we will help you interpret either drug and navigate the best treatment plan for you. Here is what is different about each medication, and how we can customize them to help you.

Breaking Down the Differences

Chemical Composition Matters

Clomiphene (Clomid) contains two components: enclomiphene (62%) and zuclomiphene (38%). While both affect estrogen receptors, zuclomiphene’s estrogen-like activity often causes unwanted effects. Pure enclomiphene eliminates this issue, providing cleaner hormonal modulation.

The Effects of Estrogen: An Important Note

Because Clomiphene both blocks and mimics estrogen, there may be variability and potential mood swings, waterfall retention and other side effects of estrogen. Enclomiphene has no estrogen mimicking effect and as a result, it is more predictable as a medication without the side effects of the estrogen.

Testosterone Optimization
For men seeking natural testosterone boosts, enclomiphene typically delivers stronger, more consistent increases (around 200 ng/dL in studies). Clomiphene can work but often with less dramatic results and more side effects.

Side Effect Profiles
Patients using clomiphene sometimes report vision changes, emotional fluctuations, or bloating—issues tied to its zuclomiphene content. Enclomiphene users generally experience fewer adverse effects, making it better tolerated long-term.

Best Clinical Applications

  • Clomiphene remains preferred for female infertility (its FDA-approved use)
  • Enclomiphene excels for male testosterone support and post-cycle therapy
  • Both can aid fertility, but enclomiphene avoids estrogenic drawbacks in men

Customization Options at Allure Compounding Pharmacy

We transform these medications into precision therapies through:

Tailored Formulations

  • Enclomiphene capsules (25-50mg)

Personalized Dosing Strategies

  • Starting low and adjusting based on bloodwork
  • Gender-specific protocols
  • Fertility-focused vs. testosterone-optimization approaches

Ongoing Monitoring Support
We collaborate with your provider to track:
✓ Testosterone/estrogen levels
✓ LH/FSH response
✓ Symptom improvement

Which Option Is Right for You?

Consider Clomiphene If:

  • You’re a woman with PCOS or infertility
  • Cost is a primary factor (generic available)
  • You can tolerate potential estrogenic effects

Choose Enclomiphene If:

  • You’re a man with low testosterone
  • You want to minimize side effects
  • You need reliable T-level improvements
  • You’re post-cycle and want clean recovery

Why Compounded Versions Make the Difference

✔ No unnecessary additives (like dyes or lactose in some brands)
✔ Flexible dosing (not limited to commercial tablet strengths)
✔ Combination potential (add DHEA, vitamins, or other supports)
✔ Freshly prepared for optimal potency

Take the Next Step Toward Hormonal Balance

Whether you’re addressing fertility, low T, or post-cycle recovery, we’ll help you navigate these options for optimal results.

Contact Allure Compounding Pharmacy today to discuss your personalized solution.