Could Low-Dose Naltrexone (LDN) Be the Missing Piece in Your Sjogren’s Management?

Sjogren’s syndrome is much more than just dry eyes and mouth. It is an autoimmune disorder of extreme complexity, often associated with extreme levels of fatigue, joint pain and systemic inflammation in the body. While traditional treatments often pursue symptom relief, low-dose naltrexone (LDN) shifts the mechanism of treatment to empower the immune system to prevent autoimmune attacks. At Allure Compounding Pharmacy, we are able to create a customized LDN product, considering both type and dosage options, that may be of additional benefit when conventional standard of care fails.

How LDN Works in Sjogren’s Syndrome

Unlike standard naltrexone (used for addiction), LDN (typically 0.5–4.5mg) works differently:

✔ Endorphin Boost: Briefly blocks opioid receptors, triggering the body to produce more endorphins—natural compounds that reduce inflammation
✔ Immune Regulation: Helps normalize overactive immune responses (key in autoimmune diseases)
✔ Neuroprotection: May protect nerve endings (helpful for Sjogren’s-related neuropathy)

Potential Benefits of LDN for Sjogren’s

1. Reduces Glandular Inflammation

  • May improve saliva and tear production (some patients report less reliance on artificial tears)
  • Helps with dry skin and vaginal dryness

2. Decreases Fatigue & Brain Fog

  • Many patients report improved energy within weeks
  • May support better sleep quality (common issue in Sjogren’s)

3. Eases Joint and Muscle Pain

  • Reduces inflammatory cytokines linked to pain
  • Often allows lower doses of NSAIDs or steroids

4. Addresses Systemic Symptoms

  • Emerging research suggests benefits for neuropathy, interstitial cystitis, and IBS (common Sjogren’s comorbidities)

How We Customize LDN for Sjogren’s Patients

1. Precision Dosing

  • Start low (0.5–1.5mg) to minimize side effects
  • Gradually increase to 3–4.5mg based on response

2. Specialized Formulations

  • Liquid LDN (for easy dose adjustments)
  • Capsules with filler-free options (for sensitive patients)
  • Time-release versions (to minimize sleep disturbances)

3. Combination Therapies

  • Paired with omega-3s or curcumin for added anti-inflammatory effects
  • Integrated with pregabalin for neuropathy support

What to Expect When Starting LDN

Typical Timeline

  • Week 1–2: Some notice improved sleep or mild energy boost
  • Month 1–3: Gradual reduction in dryness/pain (varies by patient)
  • Month 6+: Optimal effects for most

Possible Side Effects (Usually Temporary)

  • Vivid dreams (often resolves in 1–2 weeks)
  • Mild headache or nausea (less likely with slow titration)

Why Choose Compounded LDN?

✔ No unnecessary additives (commercial tablets must be split, risking inaccurate dosing)
✔ Flexible dosing (critical for Sjogren’s patients, who often need lower doses)
✔ Custom delivery methods (liquids for those with swallowing difficulties)

Is LDN Right for You?

LDN isn’t a cure, but for many Sjogren’s patients, it’s become a game-changing part of their regimen.

Contact Allure Compounding Pharmacy today to discuss personalized LDN options with your provider.